Health Literate

Health Literate

How Your Gut Tells Friend From Foe

the science of oral tolerance, why your body doesn't attack your food, and a few herbs that support the process

Agy | Health Literate's avatar
Agy | Health Literate
Jul 29, 2026
∙ Paid

Hi! Welcome back to another deep-dive of gut immunology :)

In this issue:

  • What oral tolerance is and why your gut cannot function without it

  • How your body sorts a harmless antigen from a dangerous one

  • The cells that carry that decision out and make it stick

  • Why tolerance travels through the whole body while inflammation stays put in the gut

  • How a few common plants support the gut barrier, and how licorice constituents drove its effect on regulatory T cells

Okay so, I decided on this topic while studying for my immunology course conference, where I had to learn the ins and outs of it (like I had to memorize the whole thing).

Learning how the body tells friend from foe, particularly in the gastrointestinal tract, was fun because it let me connect a few dots between this topic and past research I’ve done, specifically on autoimmunity and Treg cells. I wanted to share this topic and explain it because I know a lot of us deal with food sensitivities and allergies, and since the food quality in the US isn’t really the best, it helps to understand why our bodies react the way they do to an organic piece of bread compared to something store bought and highly processed. I know you know what I mean.

I’m going to walk you through what happens cellularly, AND a few herbs to help the process along. :)


Okay, So How Much Is Your Gut Handling?

Let’s start here, with the numbers, because they’re a little unhinged…

User's avatar

Continue reading this post for free, courtesy of Agy | Health Literate.

Or purchase a paid subscription.
© 2026 Agy · Publisher Terms
Substack · Privacy ∙ Terms ∙ Collection notice
Start your SubstackGet the app
Substack is the home for great culture